Kisspeptin-10 (10mg)

Kisspeptin-10 is the minimal active C-terminal decapeptide sequence derived from the precursor KISS1 gene product. Functioning as a high-affinity endogenous ligand for the G protein-coupled receptor KISS1R (GPR54), Kisspeptin-10 serves as a master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. In neuroendocrine research models, Kisspeptin-10 binding triggers intracellular calcium mobilization, stimulating the hypothalamic secretion of Gonadotropin-Releasing Hormone (GnRH), which subsequently drives Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) release. Beyond reproductive endocrinology, Kisspeptin signaling pathways are widely evaluated in cellular biology for their role in tumor metastasis suppression, metabolic integration, and limbic system activity. True Lab Peptides supplies Kisspeptin-10 at an independently verified purity threshold of $\ge$99%, providing qualified research institutions with a reliable standard for precision analytical studies.

Key Research Applications

• Neuroendocrine & HPG Axis Signaling: Engineered to investigate KISS1R/GPR54 receptor binding dynamics, intracellular $\text{IP}_3$/$\text{DAG}$ cascades, and GnRH secretion mechanics.

• Gonadotropin Modulation: Ideal for studying upstream regulation of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) release dynamics in vitro.

• Metastasis Suppression & Cellular Motility: Utilized to observe cell migration inhibition, focal adhesion signaling, and invasion suppression pathways in oncological cell models.

• Analytical Characterization: Serves as a high-grade reference standard for High-Performance Liquid Chromatography (HPLC) and quantitative mass spectrometry workflows.

Technical Specifications

• Compound Name: Kisspeptin-10

• Amino Acid Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

• CAS Number: 374675-21-5

• Molecular Formula: $\text{C}_{63}\text{H}_{83}\text{N}_{17}\text{O}_{14}$

• Molecular Weight: 1302.45 g/mol

• Purity Grade: $\ge$99% (COA-Verified)

• Physical Form: Lyophilized Powder

• Net Quantity: 10 mg per vial

• Category Focus: Neuroendocrine Research

Quality Assurance & Laboratory Protocols

Every batch of Kisspeptin-10 undergoes rigorous third-party analytical validation—including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)—to confirm exact decapeptide sequence identity, structural purity, and molecular weight accuracy. Batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS) are accessible to support full institutional research compliance.

Storage Instructions: Store unopened lyophilized vials in a dry, dark environment at $-20^\circ\text{C}$. Following initial reconstitution for laboratory workflows, maintain under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$. Refer to the product Safety Data Sheet (SDS) for complete chemical handling guidance.

Research Disclaimer: This product is strictly supplied for in vitro, analytical, and laboratory research purposes only. It is not intended for human or veterinary use, consumption, administration, injection, diagnostic procedures, or therapeutic applications.