IGF-1 LR3 / Long R3 Insulin-Like Growth Factor-1 (1mg)

IGF-1 LR3 (Long $\text{R}^3$ Insulin-Like Growth Factor-1) is a synthetic recombinant analog of human IGF-1 modified by replacing glutamic acid with arginine at position 3 and extending the N-terminus sequence by 13 amino acids. These structural modifications significantly decrease its affinity for IGF-Binding Proteins (IGFBPs), preventing premature inactivation and drastically extending its biological half-life compared to native IGF-1. In cellular and musculoskeletal research models, IGF-1 LR3 is widely evaluated for its potent activation of the Akt/mTOR pathway, myoblast proliferation and differentiation, satellite cell recruitment, and glucose uptake signaling dynamics. True Lab Peptides supplies IGF-1 LR3 at an independently verified purity threshold of $\ge$99%, offering qualified research institutions a reliable standard for high-precision analytical studies.

Key Research Applications

• Musculoskeletal Signaling & Hypertrophy: Engineered to investigate myoblast proliferation, satellite cell activation, and protein synthesis cascades via Akt/mTOR signaling pathways.

• IGFBP Binding Dynamics & Half-Life Extension: Ideal for studying reduced binding protein affinity, receptor availability retention, and extended signaling potency relative to native human IGF-1.

• Nutrient Uptake & Cellular Metabolism: Utilized to evaluate insulin-mimetic glucose transport, amino acid uptake, and cellular metabolic adaptation models in vitro.

• Analytical Characterization: Serves as a high-grade reference standard for High-Performance Liquid Chromatography (HPLC) and quantitative mass spectrometry workflows.

Technical Specifications

• Compound Name: IGF-1 LR3 (Long $\text{R}^3$ Insulin-Like Growth Factor-1)

• CAS Number: 946870-92-4

• Molecular Formula: $\text{C}_{400}\text{H}_{625}\text{N}_{111}\text{O}_{115}\text{S}_{9}$

• Molecular Weight: 9117.6 g/mol

• Purity Grade: $\ge$99% (COA-Verified)

• Physical Form: Lyophilized Powder

• Net Quantity: 1 mg per vial

• Category Focus: Musculoskeletal Signaling & Tissue Response Research

Quality Assurance & Laboratory Protocols

Every batch of IGF-1 LR3 undergoes rigorous third-party analytical validation—including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)—to confirm sequence integrity, primary structure, and purity standards. Batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS) are accessible to support full institutional research compliance.

Storage Instructions: Store unopened lyophilized vials in a dry, dark environment at $-20^\circ\text{C}$. Following initial reconstitution for laboratory workflows, maintain under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$. Refer to the product Safety Data Sheet (SDS) for complete chemical handling guidance.

Research Disclaimer: This product is strictly supplied for in vitro, analytical, and laboratory research purposes only. It is not intended for human or veterinary use, consumption, administration, injection, diagnostic procedures, or therapeutic applications.