GLP-1 SM / Semaglutide (10mg, & 20mg)

GLP-1 SM (Semaglutide) is a long-acting synthetic GLP-1 receptor agonist modified with a fatty acid chain that facilitates strong albumin binding and shields the peptide from enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). In laboratory and metabolic research environments, Semaglutide is extensively studied for its ability to bind selectively to GLP-1 receptors, stimulating glucose-dependent insulin secretion, suppressing glucagon release, and activating central nervous system pathways involved in appetite and energy balance regulation. True Lab Peptides supplies GLP-1 SM at an independently verified purity threshold of $\ge$99%, providing qualified research institutions with a reliable standard for precision experimental studies.

Key Research Applications

• GLP-1 Receptor Signaling: Engineered to investigate receptor-mediated cyclic AMP (cAMP) accumulation, insulinotropic activation, and glucose homeostasis kinetics in cellular models.

• Metabolic Pathway & Energy Balance Modeling: Ideal for studying central satiety pathways, gastric emptying dynamics, and hypothalamic receptor interaction.

• Enzymatic Stability & Pharmacokinetics: Utilized to evaluate albumin-binding modifications, resistance to DPP-4 cleavage, and extended peptide clearance half-lives in vitro.

• Analytical Characterization: Serves as a high-grade reference standard for High-Performance Liquid Chromatography (HPLC) and quantitative mass spectrometry workflows.

Technical Specifications

• Compound Name: GLP-1 SM (Semaglutide)

• CAS Number: 910463-68-2

• Molecular Formula: $\text{C}_{187}\text{H}_{291}\text{N}_{45}\text{O}_{59}$

• Molecular Weight: 4113.58 g/mol

• Purity Grade: $\ge$99% (COA-Verified)

• Physical Form: Lyophilized Powder

• Net Quantity Options: 5 mg, 10 mg, or 20 mg per vial

• Category Focus: Metabolic Pathway Research

Quality Assurance & Laboratory Protocols

Every batch of GLP-1 SM undergoes rigorous third-party analytical validation—including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)—to confirm exact sequence integrity, molecular weight accuracy, and purity standards. Batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS) are accessible to support full institutional research compliance.

Storage Instructions: Store unopened lyophilized vials in a dry, dark environment at $-20^\circ\text{C}$. Following initial reconstitution for laboratory workflows, maintain under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$. Refer to the product Safety Data Sheet (SDS) for complete chemical handling guidance.

Research Disclaimer: This product is strictly supplied for in vitro, analytical, and laboratory research purposes only. It is not intended for human or veterinary use, consumption, administration, injection, diagnostic procedures, or therapeutic applications.