FOXO4-DRI (10mg)

FOXO4-DRI (D-Retro-Inverso) is a specialized senolytic peptide designed to target and selectively eliminate senescent cells. Built using D-amino acids in a reverse sequence orientation, FOXO4-DRI possesses enhanced enzymatic stability against proteolytic degradation. The peptide acts by selectively disrupting the interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein. In non-senescent cells, p53 maintains normal cell function, but in senescent cells, FOXO4 sequesters p53 in the nucleus, preventing programmed cell death. By interfering with this binding, FOXO4-DRI causes nuclear exclusion of p53, triggering targeted apoptosis in senescent cells without damaging healthy tissue. True Lab Peptides supplies FOXO4-DRI at an independently verified purity threshold of $\ge$99%, providing research institutions with a reliable standard for cellular longevity and senolytic modeling.

Key Research Applications

• Senolytic Pathway & Apoptosis Research: Engineered to investigate selective apoptosis induction in senescent cells via targeted disruption of FOXO4-p53 binding complexes.

• Proteolytic Stability Studies: Ideal for evaluating D-retro-inverso chemical modifications, enzyme degradation resistance, and enhanced peptide half-life dynamics.

• Cellular Longevity & Tissue Regeneration: Utilized to observe clearance of senescent cell burdens, reduction of the Senescence-Associated Secretory Phenotype (SASP), and tissue homeostasis restoration.

• Analytical Characterization: Serves as a high-grade reference material for High-Performance Liquid Chromatography (HPLC) and quantitative mass spectrometry workflows.

Technical Specifications

• Compound Name: FOXO4-DRI (FOXO4 D-Retro-Inverso)

• Purity Grade: $\ge$99% (COA-Verified)

• Physical Form: Lyophilized Powder

• Net Quantity: 10 mg per vial

• Category Focus: Cellular Longevity & Tissue Response Research

Quality Assurance & Laboratory Protocols

Every batch of FOXO4-DRI undergoes rigorous third-party analytical validation—including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS)—to confirm exact sequence identity, purity, and molecular structure. Batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS) are accessible to support complete institutional research compliance.

Storage Instructions: Store unopened lyophilized vials in a dry, dark environment at $-20^\circ\text{C}$. Following initial reconstitution for laboratory workflows, maintain under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$. Refer to the product Safety Data Sheet (SDS) for complete chemical handling instructions.

Research Disclaimer: This product is strictly supplied for in vitro, analytical, and laboratory research purposes only. It is not intended for human or veterinary use, consumption, administration, injection, diagnostic procedures, or therapeutic applications.